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PRIMALHYAL™ 300
Provided by Givaudan
About
PRIMALHYAL™ 300 acts as an antimicrobial agent used in cosmetic applications. It is an average molecular weight hyaluronic acid (HA) (100-300 kDa) obtained by biotechnology. Shelf life: 365 days.
Benefits:
- Stimulates and strengthens skin defenses
- Helps maintain an effective protective barrier against contamination from harmful bacteria
- Displays cellular repair and wound healing
- Preservative-free, water-soluble
- China listed and COSMOS approved
Typical Applications:
Ideal for baby care, oily skin, specific care for acne-prone skin and after shave & after-sun products. It is suitable for mature, sensitive, and irritated skin.
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| Grade Name | 300 |
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About givaudan
Part of the Fragrances & Beauty Division, Givaudan Active Beauty offers an extensive portfolio of innovative award-winning active cosmetic ingredients designed to bring beauty to the world through an expanded range of benefits including anti-ageing, self-tanning, soothing...and more. Our cutting-edge technologies draw on advanced and applied sciences and nature to create high-performing molecules and functional agents, including customised carrier systems.

Antimicrobial Hyaluronic Acid for Sensitive & Acne-Prone Skin
PRIMALHYAL™ 300 is a medium molecular weight hyaluronic acid (100–300 kDa) obtained through biotechnology and fermentation, designed to deliver both antimicrobial protection and skin-repairing benefits in cosmetic formulations. Listed under the INCI name Hydrolyzed Hyaluronic Acid, it stands out from conventional HA grades by combining barrier reinforcement with active defense against harmful bacteria — without the use of preservatives.
At the cellular level, PRIMALHYAL™ 300 works by stimulating and strengthening the skin’s natural defense mechanisms, helping maintain an effective protective barrier against microbial contamination. Its molecular weight range makes it particularly suited for skin penetration and cellular interaction, supporting repair processes and wound healing — properties that go well beyond standard moisturization.
Thanks to its preservative-free, water-soluble powder form, PRIMALHYAL™ 300 integrates seamlessly into a wide range of aqueous cosmetic formulations. It is especially recommended for baby care products, oily and acne-prone skin formulations, after-shave and after-sun preparations, as well as products targeting mature, sensitive, or irritated skin — applications where both safety profile and efficacy are non-negotiable.
From a regulatory standpoint, PRIMALHYAL™ 300 is China-listed and COSMOS-approved, making it a versatile ingredient for brands targeting both European and Asian markets. Distributed by Safic-Alcan, it offers formulators a biotechnology-derived, clean-label solution that meets the growing demand for multifunctional, preservative-free active ingredients in modern skincare.