Gnosis By Lesaffre

LIFEINU™ BACILLUS SUBTILIS CU1

Probiotic suitable for nutraceutical applications. It is an active dried bacteria (bacillus subtilis) strain. Shelf life: 24 months.

QUATREFLORA™ BIOTIC

Quatreflora™ is a proprietary, patented probiotic yeast strain used in nutraceutical applications, developed by Lesaffre for women's intimate and vaginal health support through an oral, gut-to-vagina mode of action.Key Benefits:• Registered strain Saccharomyces cerevisiae CNCM I-3856, backed by 2 clinical studies and 3 preclinical (in vivo) studies• Demonstrated migration from the intestine to the vaginal environment following oral administration, detected in vaginal samples in a dedicated clinical study, enabling a dual gut and vaginal mode of action from a single oral intake• Positioned for vaginal microbiota balance, antifungal support against Candida albicans, antibacterial activity against Gardnerella vaginalis, and reduction of recurrence of vaginal infections (vulvovaginal candidiasis, bacterial vaginosis)• Convenient oral administration format as an alternative to local vaginal care routines, supporting better compliance• Yeast-based probiotic format: naturally resistant to gastric acid and bile salts, unaffected by antibiotic therapy, no protective encapsulation required• EU QPS status, non-GMO, gluten-free, lactose-free, suitable for Kosher, Halal, vegetarian and vegan diets• Available in two grades: SPI (rod-shape/vermicelli) and PW (powder), both easy to formulate into capsules or sachets• Recommended dosage: 2.5 billion CFU/day (1 to 2 capsules), corresponding to 320 mg of commercial product per day• Shelf life: 24 months in original vacuum-sealed packaging, stored cool (<25°C) and dry (<60% RH)• Produced by Gnosis by Lesaffre and distributed by Safic-AlcanTypical Applications: Vaginal probiotic / intimate health yeast / feminine microbiota support ingredient for nutraceutical formulations targeting vaginal comfort, recurrent intimate discomfort, and microbiota balance for women. Suitable for capsules, sticks and sachets[HJ4.1]. Complementary ingredient for women's health product lines addressing broader life-stage needs (fertility, pregnancy, menopause, healthy aging), and for combination formulas alongside digestive-comfort probiotic yeasts such as Lynside® Pro SCB, subject to compatibility testing.

LYNSIDE® NUTRI ORGANIC BA10 PW

Organic inactivated dried yeast (wheat) suitable for nutraceutical applications. Shelf life: 2 years.

IBSIUM®

ibSium® is a proprietary, patented probiotic yeast strain used in nutraceutical and dietary supplement applications, developed by Lesaffre for digestive comfort and gut balance support.Key Benefits:• Registered strain Saccharomyces cerevisiae CNCM I-3856, exclusive to Lesaffre, developed through a dedicated clinical substantiation program• Positioned for digestive comfort, bloating relief, abdominal comfort, and bowel habit balance, relevant to irritable bowel and functional digestive discomfort formulations• Yeast-based probiotic format: naturally resistant to gastric acid and bile salts, no encapsulation or protective coating required, unaffected by antibiotic therapy• Transient, non-colonizing mode of action, supporting a balanced gut microbiota without permanent strain implantation• US GRAS (FDA 21 CFR §172.896) and EU QPS status, non-GMO, gluten-free, lactose-free, suitable for Kosher, Halal, vegetarian and vegan diets• High stability: 18 months at ambient temperature, no cold chain required[HJ1.1]• Available in powders and vermicelli• Recommended dosage: 4 billion CFU/day (1 to 2 capsules)• Not recommended for individuals in fragile health conditions (severely immunocompromised individuals, critically ill or extremely premature infants), consistent with standard probiotic yeast precautions[HJ2.1][TU2.2]• Produced by Gnosis by Lesaffre and distributed by Safic-AlcanTypical Applications:Probiotic yeast / digestive comfort probiotic / gut microbiota support ingredient for dietary supplements and nutraceutical formulations targeting occasional digestive discomfort, bloating, irregular transit, and general gut wellness. Suitable for capsules, sachets, and stick pack formats. Complementary ingredient for gut-health product lines, including formulations supporting digestive comfort alongside GLP-1 weight-management treatments, and for combination formulas with complementary probiotic strains such as Lactobacillus rhamnosus GG.

Lynside S.Boulardii PW 20

Lynside® Pro SCB is a proprietary, patented probiotic yeast strain used in nutraceutical applications, developed by Lesaffre for digestive and immune health support, including compatibility with antibiotic therapy.Key Benefits:• Registered strain Saccharomyces cerevisiae var. boulardii CNCM I-3799, backed by an extensive clinical research programme spanning several decades• Positioned for digestive health support: acute diarrhea in children, occasional traveler's diarrhea, and gut microbiota support during antibiotic-associated digestive disruption• Eukaryotic yeast structure: naturally unaffected by antibiotic treatment, allowing simultaneous intake without loss of efficacy• Naturally resistant to gastric acid and bile salts, no protective encapsulation required• No colonization effect: transient action, cleared from the gastrointestinal tract within 3 to 5 days after discontinuation, preserving the native gut microbiota balance• US GRAS and EU QPS status, non-GMO, gluten-free, lactose-free, suitable for Kosher, Halal, vegetarian and vegan diets• Superior stability: 3 to 5 years at ambient temperature, available in rod-shape (vermicelli) and powder formats• Recommended dosage: approximately 5 billion CFU/day (200 to 250 mg)• Produced by Gnosis by Lesaffre and distributed by Safic-AlcanTypical Applications: Saccharomyces boulardii / probiotic yeast for antibiotic-compatible formulations, digestive health, travel wellness, and immune support product lines. Suitable for capsules and sachets. Complementary ingredient for gut-health and immune-support ranges, including combination formulas with prebiotic yeast fractions or bacterial probiotic strains.

ibSium® PW 8

Probiotics used in nutraceuticals and dietary supplements. It is a proprietary yeast strain selected by Lesaffre which belongs to the species Saccharomyces cerevisiae. Shelf life: 3 years.Benefits:US GRAS, FDA 21 CFR §172.896 and EU QPS certifiedIt is used to treat fragile health conditions (such as high-risk immune-compromised individuals, critically sick infants and pre-term infants) It is free from GMO